A triple-mode strategy combining low-temperature photothermal, photodynamic, and chemodynamic therapies for treating infectious skin wounds
Ruichen Ma, Shaopeng Liu, Genhua Liu, Peng Liu, Kaiyong Cai
Abstract
experimental results showed that MOF@ICG MPs had excellent antibacterial properties and good cytocompatibility, with some ability to promote the migration of L-929 fibroblasts. Furthermore, under NIR irradiation, MOF@ICG NPs could significantly kill bacteria and promote skin wound healing according to the results of animal experiments. The wound healing rate reached 87.1% after 7 days of treatment. The research results break through the limitations of single-mode antibacterial technology and provide certain theoretical guidance and technical support for the research and development of new antibacterial materials.
Topics & Concepts
Photothermal therapyPhotodynamic therapyChemistrySkin reactionMicrobiologyMedicineNanotechnologyDermatologyMaterials scienceBiologyOrganic chemistryNanoplatforms for cancer theranosticsWound Healing and TreatmentsPhotodynamic Therapy Research Studies