B Lymphocyte Development in the Bursa of Fabricius of Young Broilers is Influenced by the Gut Microbiota
Jiaheng Cheng, Huangtao Lei, Chunlin Xie, Jianwei Chen, Xinyu Yi, Fang Zhao, Yushan Yuan, Peng Chen, Jingyi He, Chenglong Luo, Dingming Shu, Hao Qu, Jian Ji
Abstract
at single-cell resolution. Furthermore, we determined a new pivotal regulator (Taf1) of B cell differentiation. We believe that our study makes a significant contribution to the literature because our findings may elucidate the role of the gut microbiota in B cell differentiation. This study also serves as a basis for developing new strategies that modulate B cell differentiation to prevent diseases.
Topics & Concepts
Bursa of FabriciusBiologyGut floraImmune systemTranscriptomeImmunologyMicrobiomeRegulatory T cellB cellMicrobiologyT cellGeneticsGene expressionGeneAntibodyIL-2 receptorGut microbiota and healthImmune Cell Function and InteractionClostridium difficile and Clostridium perfringens research