Neuroprotective effect of hydrogen sulfide against glutamate-induced oxidative stress is mediated via the p53/glutaminase 2 pathway after traumatic brain injury
Jianping Sun, Xiaoyu Li, Xiaoyu Gu, Hailong Du, Gengshen Zhang, Jianliang Wu, Feng Wang
Abstract
S protects brain injury induced by TBI through modulation of the glutamate-mediated oxidative stress in the p53/GLS-2 pathway-dependent manner.
Topics & Concepts
NeuroprotectionGlutamate receptorOxidative stressGlutaminaseTraumatic brain injuryHydrogen sulfideChemistryNeurosciencePharmacologyBiochemistryMedicineBiologyPsychiatrySulfurReceptorOrganic chemistrySulfur Compounds in BiologyTraumatic Brain Injury and Neurovascular DisturbancesBiochemical effects in animals