Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells
Gerard L. Brien, Raul Bardini Bressan, Craig Monger, Dáire Gannon, Eimear Lagan, Anthony M. Doherty, Evan Healy, Hannah K. Neikes, Darren J. Fitzpatrick, Orla Deevy, Vivien Grant, María Ángeles Marqués‐Torrejón, Neza Alfazema, Steven M. Pollard, Adrian P. Bracken
Topics & Concepts
BiologyPRC2EnhancerHistone H3ChromatinEpigenomicsHistoneGeneticsCell biologyEZH2Polycomb-group proteinsRegulation of gene expressionCancer researchGeneRepressorGene expressionDNA methylationEpigenetics and DNA MethylationGlioma Diagnosis and TreatmentGenomics and Chromatin Dynamics