An “eat me” combinatory nano-formulation for systemic immunotherapy of solid tumors
Hend Mohamed Abdel‐Bar, Adam A. Walters, Yau Mun Lim, Nadia Rouatbi, Yue Qin, Fatemeh Gheidari, Shunping Han, Rihab Osman, Julie Wang, Khuloud T. Al‐Jamal
Abstract
Therefore, the combination of siCD47 and Dox in a particulate system showed potent anti-tumor activity which merits further investigation in future clinical studies.
Topics & Concepts
Small interfering RNAIn vivoCalreticulinGene silencingApoptosisIn vitroDoxorubicinCytotoxicityChemistryImmune systemCancer researchPharmacologyCell biologyBiologyRNAImmunologyBiochemistryChemotherapyGeneBiotechnologyGeneticsEndoplasmic reticulumRNA Interference and Gene DeliveryPhagocytosis and Immune RegulationNanoparticle-Based Drug Delivery