The N-terminal tail of <i>C. elegans</i> CENP-A interacts with KNL-2 and is essential for centromeric chromatin assembly
Christian de Groot, Jack Houston, Bethany Davis, Adina Gerson‐Gurwitz, Joost Monen, Pablo Lara-González, Karen Oegema, Andrew K. Shiau, Arshad Desai
Abstract
and partially substitutes for the function of Scm3/HJURP, in that it mediates a direct interaction between CENP-A and KNL-2. These results highlight an evolutionary variation on centromeric chromatin assembly in the absence of a dedicated CENP-A-specific chaperone/targeting factor of the Scm3/HJURP family.
Topics & Concepts
BiologyCentromereChromatinCaenorhabditis elegansCell biologyNucleosomeGeneticsHistoneHistone H1ChromosomeDNAGeneChromosomal and Genetic VariationsPlant Reproductive BiologyGenomics and Chromatin Dynamics