Conformational buffering underlies functional selection in intrinsically disordered protein regions
Nicolás S. González Foutel, Juliana Glavina, Wade M. Borcherds, Matías Safranchik, Susana Barrera-Vilarmau, Amin Sagar, Alejandro Estaña, Amélie Barozet, Nicolás A. Garrone, Gregorio Fernández‐Ballester, Clara Blanes‐Mira, Ignacio E. Sánchez, Gonzalo de Prat-Gay, Juan Cortés, Pau Bernadó, Rohit V. Pappu, Alex S. Holehouse, Gary W. Daughdrill, Lucía B. Chemes
Topics & Concepts
LinkerIntrinsically disordered proteinsCoevolutionBiologyMechanism (biology)Peptide sequenceComputational biologyPlasma protein bindingProtein structureGeneticsGeneCell biologyBiophysicsEvolutionary biologyBiochemistryComputer sciencePhilosophyEpistemologyOperating systemBacteriophages and microbial interactionsVirus-based gene therapy researchRNA and protein synthesis mechanisms