Chiral oxalamide phosphine (COAP)-Pd-catalyzed enantioselective cascade formal [4 + 1] annulation for enantioenriched 2,3-disubstituted indolines and further DFT study on regio- and stereocontrol
Sheng‐Suo Zhou, Junhao Shen, Wenkai Liu, Xing‐Yun Sun, Jiayu Song, Zheng Wang, Zheng‐Hang Qi, Xing‐Wang Wang
Abstract
COAP-Pd-catalyzed asymmetric cascade formal [4 + 1] annulation was developed between racemic vinyl benzoxazinones and N -tosylhydrazone sodium salts, affording trans -2,3-disubstituted indolines in good yields with high stereoselectivity.
Topics & Concepts
ChemistryAnnulationEnantioselective synthesisStereoselectivityPhosphineCascadeCatalysisCombinatorial chemistryStereochemistryMedicinal chemistryOrganic chemistryChromatographyCatalytic C–H Functionalization MethodsAsymmetric Synthesis and CatalysisAsymmetric Hydrogenation and Catalysis