<i>Lactobacillus plantarum</i> AR495 improves colonic transport hyperactivity in irritable bowel syndrome through tryptophan metabolism
Hongyun Zhang, Yongjun Xia, Guangqiang Wang, Zhiqiang Xiong, Guoliang Wei, Zhuan Liao, Yangyan Qian, Zongwei Cai, Lianzhong Ai
Abstract
AR495 could restore the normal levels of 5-HT by inhibiting the abnormal proliferation of enterochromaffin cells and the excessive activation of TPH1 to inhibit the intestinal peristalsis in IBS. These findings provide insights for the use of probiotics in the treatment of IBS and other diarrheal diseases.
Topics & Concepts
Irritable bowel syndromeLactobacillus plantarumGastroenterologyTryptophanTryptophan MetabolismChemistryInternal medicineMedicineBiochemistryBiologyLactic acidBacteriaAmino acidGeneticsGastrointestinal motility and disordersDiet and metabolism studiesGut microbiota and health