Hsa-let-7f-1-3p targeting the circadian gene Bmal1 mediates intervertebral disc degeneration by regulating autophagy
Liangwei Mei, Yi Zheng, Xue Gao, Teng Ma, Bing Xia, Yiming Hao, Bin Wei, Yitao Wei, Zhuojing Luo, Jinghui Huang
Topics & Concepts
AutophagyCircadian rhythmCell biologyBiologyIntervertebral discTranscriptomeMechanism (biology)Transcription factormicroRNADegeneration (medical)Circadian clockGeneNeuroscienceGeneticsMedicineAnatomyPathologyGene expressionEpistemologyPhilosophyApoptosisSpine and Intervertebral Disc PathologyPlant Toxicity and Pharmacological PropertiesMusculoskeletal pain and rehabilitation