Molecular causality in the advent of foundation models
Sebastian Lobentanzer, Pablo Rodríguez-Mier, Stefan Bauer, Julio Sáez-Rodríguez
Abstract
Correlation is not causation: this simple and uncontroversial statement has far-reaching implications. Defining and applying causality in biomedical research has posed significant challenges to the scientific community. In this perspective, we attempt to connect the partly disparate fields of systems biology, causal reasoning, and machine learning to inform future approaches in the field of systems biology and molecular medicine.
Topics & Concepts
Causality (physics)CausationBiologyFoundation (evidence)DECIPHERPerspective (graphical)Field (mathematics)Systems biologyEngineering ethicsCausal reasoningStatement (logic)EpistemologySimple (philosophy)Data scienceComputational biologyCognitive scienceManagement scienceBioinformaticsComputer scienceArtificial intelligencePsychologyNeuroscienceEngineeringPhysicsMathematicsCognitionPolitical scienceLawQuantum mechanicsPhilosophyPure mathematicsBioinformatics and Genomic NetworksGene Regulatory Network AnalysisGene expression and cancer classification