XRCC1 prevents toxic PARP1 trapping during DNA base excision repair
Annie Albert Demin, Kouji Hirota, Masataka Tsuda, Marek Adamowicz, Richard Hailstone, Jan Bražina, William H. Gittens, Ilona Kalasová, Zhengping Shao, Shan Zha, Hiroyuki Sasanuma, Hana Hanzlíková, Shunichi Takeda, Keith W. Caldecott
Abstract
cells. These data reveal excessive PARP1 engagement during BER as a threat to genome integrity and identify XRCC1 as an "anti-trapper" that prevents toxic PARP1 activity.
Topics & Concepts
BiologyXRCC1PARP1Base excision repairDNA repairDNA damageDNAGeneticsCell biologyCancer researchMolecular biologyPoly ADP ribose polymeraseGenePolymeraseGenotypeSingle-nucleotide polymorphismPARP inhibition in cancer therapyDNA Repair Mechanisms