Sodium butyrate ameliorated diabetic nephropathy-associated tubulointerstitial inflammation by modulating the tight junctions of renal tubular epithelial cells
Tingting Yang, Lin Li, Cai Heng, Pian Sha, Yiying Wang, Jiaming Shen, Zhenzhou Jiang, Sitong Qian, Chujing Wei, Hao Yang, Xia Zhu, Tao Wang, Mengying Wu, Jianyun Wang, Qian Lü, Xiaoxing Yin
Abstract
NaB treatment could ameliorate DN-associated TI by modulating the TJs of renal tubular epithelial cells via the S1PR1/AMPK signaling pathway, leading to the improvement of TIF.
Topics & Concepts
InflammationTight junctionAMPKCell biologyEndocrinologyInternal medicineChemistryDiabetic nephropathyPharmacologyKidneyMedicineBiologyPhosphorylationProtein kinase ABarrier Structure and Function StudiesLipid metabolism and disordersAdipokines, Inflammation, and Metabolic Diseases