MicroRNA 27a Is a Key Modulator of Cholesterol Biosynthesis
Abrar A. Khan, Heena Agarwal, S. Santosh Reddy, Vikas Arige, Bhargavi Natarajan, Vinayak Gupta, Kalyani Ananthamohan, Manoj Kumar Barthwal, Nitish R. Mahapatra
Abstract
) in the cholesterol biosynthesis pathway. Taken together, miR-27a emerges as a key regulator of cholesterol biosynthesis and has therapeutic potential for the clinical management of hypercholesterolemia.
Topics & Concepts
BiologymicroRNADownregulation and upregulationCholesterolRegulatorCell biologyBiosynthesisRegulation of gene expressionReductaseGeneEnzymeBiochemistryMicroRNA in disease regulationCancer-related molecular mechanisms researchRNA Research and Splicing