The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
Mikołaj Słabicki, Zuzanna Kozicka, Georg Petzold, Yen-Der Li, Manisha Manojkumar, R.D. Bunker, Katherine A. Donovan, Quinlan Sievers, Jonas Koeppel, Dakota J. Suchyta, Adam S. Sperling, Emma C. Fink, Jessica A. Gasser, Li R. Wang, Steven M. Corsello, Rob S. Sellar, Max Jan, Dennis Gillingham, Claudia Scholl, Stefan Fröhling, Todd R. Golub, Eric S. Fischer, Nicolas H. Thomä, Benjamin L. Ebert
Topics & Concepts
Cyclin-dependent kinaseCDK inhibitorGLUECyclinChemistryCancer researchBiologyBiochemistryMaterials scienceCell cycleCellComposite materialProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysCancer-related Molecular Pathways