Nrf2-Related Therapeutic Effects of Curcumin in Different Disorders
Soudeh Ghafouri‐Fard, Hamed Shoorei, Zahra Bahroudi, Bashdar Mahmud Hussen, Seyedeh Fahimeh Talebi, Mohammad Taheri, Seyed Abdulmajid Ayatollahi
Abstract
Curcumin is a natural polyphenol with antioxidant, antibacterial, anti-cancer, and anti-inflammation effects. This substance has been shown to affect the activity of Nrf2 signaling, a pathway that is activated in response to stress and decreases levels of reactive oxygen species and electrophilic substances. Nrf2-related effects of curcumin have been investigated in different contexts, including gastrointestinal disorders, ischemia-reperfusion injury, diabetes mellitus, nervous system diseases, renal diseases, pulmonary diseases, cardiovascular diseases as well as cancers. In the current review, we discuss the Nrf2-mediated therapeutic effects of curcumin in these conditions. The data reviewed in the current manuscript indicates curcumin as a potential activator of Nrf2 and a therapeutic substance for the protection of cells in several pathological conditions.