PIK3CA gene mutations in the helical domain correlate with high tumor mutation burden and poor prognosis in metastatic breast carcinomas with late-line therapies
Yu Tang, Jing Li, Ning Xie, Xiaohong Yang, Liping Liu, Hui Wu, Can Tian, Ying He, Xiao Wang, Qiongzhi He, Zhe-Yu Hu, Quchang Ouyang
Abstract
-HD mutations.
Topics & Concepts
Metastatic breast cancerMutationProtein kinase BOncologyPI3K/AKT/mTOR pathwayProportional hazards modelCancer researchInternal medicineMedicinePoint mutationProtein kinase domainGeneBiologyBreast cancerCancerGeneticsPhosphorylationSignal transductionMutantPI3K/AKT/mTOR signaling in cancerAdvanced Breast Cancer TherapiesCancer Genomics and Diagnostics