L-lactate exerts a pro-proliferative effect on adult hippocampal precursor cells in vitro
Alexandra Pötzsch, Sara Zocher, Stefanie N. Bernas, Odette Leiter, Annette E. Rünker, Gerd Kempermann
Abstract
revealed that the pro-proliferative effect of L-lactate was not dependent on receptor activity although phosphorylation of ERK1/2 and Akt was increased following L-lactate treatment. Together, we show that availability of L-lactate is linked to the proliferative potential of NPCs and add evidence to the hypothesis that lactate influences cellular homeostatic processes in the adult brain, specifically in the context of adult hippocampal neurogenesis.
Topics & Concepts
Hippocampal formationNeurogenesisLactate dehydrogenaseGlycolysisPentose phosphate pathwayCell biologyContext (archaeology)ChemistryBiologyWarburg effectBiochemistryMetabolismEndocrinologyEnzymePaleontologyNeurogenesis and neuroplasticity mechanismsMitochondrial Function and PathologyNeuroscience and Neuropharmacology Research