Assessment of cytotoxic and antimicrobial activities of two components of Cymbopogon citratus essential oil
Carolina Chaves-Quirós, Johnatan-Stiven Usuga-Usuga, Sandra-Milena Morales-Uchima, Adriana-Patricia Tofiño-Rivera, Sergio Iván Tobón‐Arroyave, María-Cecilia Martínez-Pabón
Abstract
BACKGROUND: , citral and myrcene on human periodontal ligament fibroblast (HPLF) cultures and their antimicrobial effect on different bacterial species present in supragingival biofilm. MATERIAL AND METHODS: clinical strains by broth microdilution assay. One-way analysis of variance (ANOVA) with Games-Howell post-hoc multiple comparison or unpaired t tests were used for inter- and intragroup comparisons. RESULTS: Overall, all of the compounds under study showed a cytotoxic effect to HPLF which varied in a dose-dependant manner. Whilst myrcene did not show bacteriostatic activity at tested concentrations, both citral and CHX exhibited bacteriostatic/bactericidal effects to all strains at specific concentrations, being CHX most effective to inhibit bacterial growth at lower concentrations than what observed for citral. CONCLUSIONS: Antimicrobial activity, citral, cytotoxicity, chlorhexidine, myrcene.