Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?
Paul E. Verweij, Maiken Cavling Arendrup, Ana Alastruey‐Izquierdo, Jeremy A.W. Gold, Shawn R. Lockhart, Tom Chiller, P. Lewis White
Abstract
Azole resistance in Aspergillus fumigatus is a One Health resistance threat, where azole fungicide exposure compromises the efficacy of medical azoles. The use of the recently authorized fungicide ipflufenoquin, which shares its mode-of-action with a new antifungal olorofim, underscores the need for risk assessment for dual use of antifungals.
Topics & Concepts
FungicideAzoleAspergillus fumigatusAntifungalFluconazoleMedicineMode of actionIntensive care medicineMicrobiologyBiologyToxicologyAgronomyAntifungal resistance and susceptibilityFungal Infections and StudiesPlant Pathogens and Fungal Diseases