Construction of Spirooxindole Analogues Engrafted with Indole and Pyrazole Scaffolds as Acetylcholinesterase Inhibitors
Mohammad Shahidul Islam, Abdullah Mohammed Al‐Majid, Mohammad Azam, Ved Prakash Verma, Assem Barakat, Matti Haukka, Abdullah A. Elgazar, Amira Mira, Farid A. Badria
Abstract
values of 24.1 and 27.8 μM, respectively. Molecular docking was used to study their interaction with the active site of hAChE.
Topics & Concepts
Indole testPyrazoleChemistryAcetylcholinesteraseCombinatorial chemistryPharmacologyStereochemistryBiochemistryMedicineEnzymeCholinesterase and Neurodegenerative DiseasesSynthesis and biological activityComputational Drug Discovery Methods