Effective CD4 T cell priming requires repertoire scanning by CD301b <sup>+</sup> migratory cDC2 cells upon lymph node entry
Naoya Tatsumi, Alicia L Codrington, Jihad El-Fenej, Varoon Phondge, Yosuke Kumamoto
Abstract
DCs function as an immunological “display window” for CD4 T cells to efficiently scan their antigen specificity.
Topics & Concepts
Priming (agriculture)AntigenBiologyCell biologyLymph nodeT cellImmunologyImmune systemPolyclonal antibodiesAntigen-presenting cellBotanyGerminationT-cell and B-cell ImmunologyImmune Cell Function and InteractionImmunotherapy and Immune Responses