Identification of novel furo[2,3-<i>d</i>]pyrimidine based chalcones as potent anti-breast cancer agents: synthesis, <i>in vitro</i> and <i>in vivo</i> biological evaluation
Mai A. Mansour, Mamdouh A. Oraby, Zeinab A. Muhammad, Deena S. Lasheen, Hatem M. Gaber, Khaled A. M. Abouzid
Abstract
anticancer assessment study, where compound 5e revealed comparable results to doxorubicin.
Topics & Concepts
In vivoDoxorubicinPyrimidineChemistryIn vitroCancerCell cultureMCF-7Cytotoxic T cellPharmacologyStereochemistryBreast cancerHuman breastBiochemistryMedicineBiologyInternal medicineChemotherapyBiotechnologyGeneticsSynthesis and biological activitySynthesis and Biological EvaluationSynthesis of Organic Compounds