Palladium-catalyzed [4 + 2] cycloaddition of amido-tethered allylic carbonates with oxazol-5-(4<i>H</i>)-ones: synthesis of piperidine-2,6-dione derivatives
Lan Wang, Min Liu, Mengxi Lu, Bo Wang, Qihuan Han, Jingrong Jin, Songcheng Yu, Yongjun Wu, Hongchao Guo
Abstract
A palladium-catalyzed [4 + 2] cycloaddition of amido-tethered allylic carbonates with oxazol-5-(4 H )-ones proceeded smoothly under mild reaction conditions to give various piperidine derivatives in moderate to excellent yields.
Topics & Concepts
ChemistryPiperidineAllylic rearrangementCycloadditionCatalysisPalladiumMedicinal chemistryOrganic chemistryCyclopropane Reaction MechanismsAsymmetric Synthesis and CatalysisCatalytic Alkyne Reactions