Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration
Wenning Xu, Chun Liu, Huo‐Liang Zheng, Haixia Xu, Runze Yang, Sheng‐Dan Jiang, Li-xin Zhu
Abstract
could attenuate IVDD by upregulation of Sesn2-induced mitophagy. This study will help to further reveal the mechanism of Sesn2 regulating mitophagy, and open up new ideas for the prevention and treatment of IVDD.
Topics & Concepts
MitophagyParkinPINK1Cell biologyMitochondrionIntegrated stress responseCytosolChemistryBiologyAutophagyBiochemistryMedicineTranslation (biology)ApoptosisInternal medicineGeneEnzymeMessenger RNAParkinson's diseaseDiseaseAutophagy in Disease and TherapyParkinson's Disease Mechanisms and TreatmentsEndoplasmic Reticulum Stress and Disease