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Synthesis of ciprofloxacin-linked 1,2,3-triazole conjugates as potent antibacterial agents using click chemistry: exploring their function as DNA gyrase inhibitors <i>via in silico</i>- and <i>in vitro</i>-based studies

Upendra Kumar Patel, Punit Tiwari, Ragini Tilak, Gaurav Joshi, Roshan Kumar, Alka Agarwal

2024RSC Advances12 citationsDOIOpen Access PDF

Abstract

assay to evaluate the inhibition of DNA gyrase. The analysis revealed that compound 10b was the most potent inhibitor of DNA gyrase compared to ciprofloxacin, which was employed as the positive control. Furthermore, the structure of two title compounds (11a and 12d) was characterized using single-crystal analysis.

Topics & Concepts

DNA gyraseClick chemistryIn silicoTriazoleCiprofloxacinChemistryConjugateCombinatorial chemistryIn vitroDNAAntibacterial activityOfloxacinStereochemistryBiochemistryBiologyAntibioticsBacteriaOrganic chemistryGeneticsEscherichia coliGeneMathematical analysisMathematicsClick Chemistry and ApplicationsHIV/AIDS drug development and treatmentChemical Synthesis and Analysis
Synthesis of ciprofloxacin-linked 1,2,3-triazole conjugates as potent antibacterial agents using click chemistry: exploring their function as DNA gyrase inhibitors <i>via in silico</i>- and <i>in vitro</i>-based studies | Litcius