Cell-penetrating peptides improve pharmacokinetics and pharmacodynamics of anticancer drugs
Izabela Rusiecka, Iwona Gągało, Ivan Kocić
Abstract
) indicated that they possess several merits in comparison to the parent drugs. They concerned not only better cellular internalization but also other improvements in pharmacokinetics (e.g. access to the brain tissue) and pharmacodynamics (e.g. overcoming drug resistance). The anticancer activity of the conjugates was usually superior to that of the unconjugated drug. Certain anticancer CPPs and conjugates entered clinical trials.
Topics & Concepts
InternalizationPharmacokineticsPharmacologyIn vivoPharmacodynamicsDrugChemistryIn vitroCell-penetrating peptideCellMedicineBiologyBiochemistryBiotechnologyRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesAntimicrobial Peptides and Activities