Nitrogen-centered radicals driving unusual enzyme reactions in biosynthetic pathways

Abstract

classical polar mechanisms. This review provides an overview of the enzymatic systems discovered and characterized over the past decade that harness nitrogen-centered radicals to mediate diverse biological transformations. Emphasis is placed on the enzymatic strategies for generating and precisely controlling these reactive species, with detailed discussions of their underlying mechanisms. These insights underscore the expanding role of nitrogen radical chemistry in biology and highlight its potential in the development of new biocatalytic platforms for synthetically challenging transformations.

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