Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function
Mai Luo, Jessica N. Spradlin, Lydia Boike, Bingqi Tong, Scott M. Brittain, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, Thomas J. Maimone, Daniel K. Nomura
Topics & Concepts
Drug discoveryNatural productUbiquitin ligaseComputational biologyChemical biologySmall moleculeCereblonChemistryFunction (biology)ToolboxNanotechnologyCombinatorial chemistryUbiquitinBiologyComputer scienceBiochemistryCell biologyMaterials scienceProgramming languageGeneProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis