Inhibition of the B7-H3 immune checkpoint limits hepatocellular carcinoma progression by enhancing T lymphocyte-mediated immune cytotoxicity in vitro and in vivo
Zixiong Zhou, Xijie Yu, Yuqing Chen, Xiaodan Tan, Wenwen Liu, Wenxi Hua, Lihong Chen, Wenmin Zhang
Topics & Concepts
Immune systemMedicineCancer researchImmune checkpointAntibodyCD8Hepatocellular carcinomaCytotoxic T cellImmunityCytotoxicityImmunotherapyImmunologyLymphocyteTumor-infiltrating lymphocytesIn vitroBiologyBiochemistryCancer Immunotherapy and BiomarkersCAR-T cell therapy researchImmunotherapy and Immune Responses