Quantum Dots Encapsulated with Curcumin Inhibit The Growth of Colon Cancer, Breast Cancer and Bacterial Cells
Firdos Alam Khan, Narimane Lammari, Adeeb Shezad Muhammad Siar, Khulood Mohammed Al-Khater, Sarah Mousa Asiri, Sultan Akhtar, Iman Almansour, Widyan Alamoudi, Woroud Haroun, W. Louaer, Abdeslam Hassen Meniai, Abdelhamid Elaı̈ssari
Abstract
Aim: To synthesize and examine the impact of free Eudragit® RS 100 nanoparticles (LN01), Quantum dots curcumin-loaded Eudragit RS 100 nanoparticles (LN04), and un-encapsulated curcumin nanoparticles (LN06) on cancerous and bacterial cells. Materials & methods: The LN01, LN04, LN06 were synthesized and characterized by Fourier transform infrared, ζ potential, UV–Vis spectroscopy, transmission electron microscopy and scanning electron microscopy and their biological activities were evaluated. Results: LN04 profoundly inhibited the growth of colon (HCT-116) cancerous cells (10.64% cell viability) and breast cancer (MCF-7) cells (10.32% cell viability) with compared to LN01 and LN06. Normal cells (HEK-293) did not show any inhibition after treatments. In addition, LN04 show better inhibitory action on bacterial growth compared with LN01 and LN06. Conclusion: We suggest that LN04 selectively target cancerous and bacterial cells and therefore possess potential anticancer and antibacterial capabilities.