Gut microbiota: a perspective for colorectal cancer
Payam Gonbari Milani, Roya Abedi Soleimani, Nader Khani, Aziz Homayouni Rad
Abstract
Colorectal cancer is a major cause of cancer deaths globally, resulting in 700 000 deaths every year. It is the third most common cancer in both men and women, with approximately 1.36 million new cases reported annually. Studies suggest that the microbiota can play a significant role in preventing colon cancer and aiding recovery during intestinal inflammation. Research has shown that certain gut microorganisms, such as Lactobacillus spp, can positively impact these processes. This review explores the connection between colon cancer and gut microbiota, how probiotic bacteria can lower the risk of cancer, and the potential of using probiotics and postbiotics as an effective strategy for cancer prevention. Existing evidence indicates that specific probiotics potentially possess anticarcinogenic properties. However, additional research is required to comprehend the precise mechanisms that are specific to the host.