Discovery of intracellular self-assembly protein degraders driven by tumor-specific activatable bioorthogonal reaction
Ru Si, Ping Hai, Yongbiao Zheng, Jin Wang, Qingqing Zhang, Yanchen Li, Xiaoyan Pan, Jie Zhang, Jie Zhang
Topics & Concepts
Bioorthogonal chemistryChemistryIntracellularSmall moleculeMembrane permeabilityChimera (genetics)BiochemistryBiophysicsMembraneCombinatorial chemistryClick chemistryBiologyGeneProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisUbiquitin and proteasome pathways