Gut dysbiosis induced by cardiac pressure overload enhances adverse cardiac remodeling in a T cell-dependent manner
Francisco J. Carrillo‐Salinas, Marina Anastasiou, Njabulo Ngwenyama, Kuljeet Kaur, Albert Tai, Sasha Smolgovsky, David Jetton, Mark Aronovitz, Pilar Alcaide
Abstract
mice, or in mice depleted of the microbiota. These findings demonstrate that cardiac pressure overload induced gut dysbiosis and T cell immune responses contribute to adverse cardiac remodeling, and identify the potential contribution of tryptophan metabolites and the AhR to protection from adverse cardiac remodeling and systolic dysfunction in HF.
Topics & Concepts
DysbiosisPressure overloadBiologyGut floraHeart failureCardiac fibrosisImmune systemCardiac function curveVentricular remodelingInternal medicineEndocrinologyImmunologyMedicineCardiac hypertrophyGut microbiota and healthTryptophan and brain disordersFrailty in Older Adults