Transient- and Native-Directing-Group-Enabled Enantioselective C–H Functionalization
Chuan He, Bing Zu, Yonghong Guo, Jie Ke
Abstract
Abstract In recent years, transition-metal-catalyzed enantioselective C–H bond functionalization using chiral transient directing groups (cTDGs) or native directing groups (NDGs) has emerged as a powerful and attractive synthetic approach to streamline the synthesis of chiral molecules. This short review focuses on recent advances on imine-based cTDGs strategies and native amine and carboxylic acid directed strategies for the asymmetric functionalization of various C–H bonds. We have endeavored to highlight the great potential of this methodology and hope that this review will inspire further research in this area. 1 Introduction 2 Transient-Directing-Group-Enabled Enantioselective C–H Functionalization 2.1 Generation of Central Chirality 2.2 Generation of Axial Chirality 2.3 Generation of Planar Chirality 3 Native-Directing-Group-Enabled Enantioselective C–H Functionalization 3.1 Native Amines as Directing Groups 3.2 Native Carboxylic Acids as Directing Groups 4 Conclusions and Outlook