Strategic engineering of alkyl spacer length for a pH-tolerant lysosome marker and dual organelle localization
Suprakash Biswas, Tanoy Dutta, Akshay Silswal, Rohit Bhowal, Deepak Chopra, Apurba Lal Koner
Abstract
A series naphthalimide-based fluorophores were designed by alkyl spacer length engineering to discover a pH-tolerant lysosomal marker. This approach also allows to probe lysosome-related organelles in<italic>C. elegans</italic>and communication between organelles.
Topics & Concepts
LysosomeOrganelleAlkylDual (grammatical number)Cell biologyChemistryNanotechnologyBiochemistryBiologyMaterials scienceOrganic chemistryPhilosophyEnzymeLinguisticsAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryLipid Membrane Structure and Behavior