Development of the gonadotropin‐releasing hormone system
Anne Duittoz, Paolo E. Forni, Paolo Giacobini, Matan Golan, Patrice Mollard, Ariel L Negrón, Sally Radovick, Susan Wray
Abstract
This review summarizes the current understanding of the development of the neuroendocrine gonadotropin-releasing hormone (GnRH) system, including discussion on open questions regarding (1) transcriptional regulation of the Gnrh1 gene; (2) prenatal development of the GnRH1 system in rodents and humans; and (3) paracrine and synaptic communication during migration of the GnRH cells.
Topics & Concepts
Internal medicineEndocrinologyGonadotropinGonadotropin-releasing hormoneHormoneBiologyMedicineLuteinizing hormoneHypothalamic control of reproductive hormonesOvarian function and disordersReproductive System and Pregnancy