Glioblastoma Homing Photodynamic Therapy Based on Multifunctionalized Porous Silicon Nanoparticles
Rae Hyung Kang, Youngwoong Kim, Hye Ji Um, Jaehoon Kim, Eun‐Kyoung Bang, Seung Geun Yeo, Dokyoung Kim
Abstract
Photodynamic therapy (PDT) is a clinically approved minimally invasive therapy for malignant diseases. Indocyanine green (ICG) is a prominent photosensitive agent for PDT, but it has intrinsic drawbacks such as aggregation, instability, and photolytic degradation. Although numerous nanoparticle-based approaches have been studied to overcome such issues, there are still limitations such as potential immunogenicity and unprecise and inefficient delivery to the tumor. In this study, we disclosed a nanoformulation (SIWV-pSiNP(ICG)), SIWV peptide-functionalized glioblastoma (GBM) homing, and ICG-incorporated porous silicon nanoparticles (pSiNPs). The nanoformulation demonstrated an enhanced photodynamic property under NIR light irradiation with improved stability of the incorporated ICG. The SIWV-pSiNP(ICG) also showed significant targeting ability to the GBM cells with nontoxicity and laser-triggered ROS generation in situ. As a result, the SIWV-pSiNP(ICG) showed superior therapeutic efficacy (anticancer efficiency) with excellent biocompatibility in the GBM xenograft mice. This work presents a novel and efficient strategy to enhance PDT efficacy for the targeted GBM therapy.