EGF promotes <i>DKK1</i> transcription in hepatocellular carcinoma by enhancing the phosphorylation and acetylation of histone H3
Jie Niu, Wei Li, Chao Liang, Xiao Wang, Xin Yao, Ruohan Yang, Zhansheng Zhang, Han-Fang Liu, Fan‐Ye Liu, Shuhua Pei, Wenqi Li, Hua Sun, Dong Fang, Songqiang Xie
Abstract
Growth factor–induced parallel pathways stimulate DKK1 expression and metastasis in liver cancer.
Topics & Concepts
Hepatocellular carcinomaDKK1AcetylationPhosphorylationHistoneCancer researchMetastasisTranscription factorChemistryInternal medicineBiologyCell biologySignal transductionCancerMedicineBiochemistryWnt signaling pathwayGeneUbiquitin and proteasome pathwaysCancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer