Osteoimmunology: An Overview of the Interplay of the Immune System and the Bone Tissue in Fracture Healing
Rayan Ben Letaifa, Tarek Klaylat, Magdalena Tarchala, Chan Gao, Prism Schneider, Derek H. Rosenzweig, Paul A. Martineau, Rahul Gawri
Abstract
Bone healing occurs through three consecutive and interdependent phases. While the acute inflammatory response is vital to fracture healing, chronic and systemic inflammation negatively affect the healing process. The bone tissue relies heavily on the immune system for its normal physiology and turnover. The interactions are more pronounced in injury states, such as fractures and autoimmune disorders. Recently, the field of osteoimmunology, the study of the molecular interplay of the immune and skeletal systems, has gained much-needed attention to develop new therapeutic strategies to accelerate fracture healing and prevent the complications of fracture healing. This review provides an overview of the process of fracture healing and discusses the role of immune cells, their interplay with the released cytokines, and the current state of the art in the field of osteoimmunology.