Visible light driven multicomponent synthesis of difluoroamidosulfonyl quinoline derivatives
Haiwei Ye, Liping Zhou, Yunhua Chen, Huaguang Tong
Abstract
-allylbromodifluoroacetamides with the insertion of sulfur dioxide has been developed. Diverse difluoroamidosulfonylated quinolines are obtained in moderate to good yields. This protocol features broad functional group tolerance and high regioselectivity. Moreover, mechanistic studies reveal the involvement of the radical pathway and the formation of an electron donor-acceptor (EDA) complex in this reaction.
Topics & Concepts
RegioselectivityQuinolineTandemChemistryVisible spectrumFunctional groupPhotocatalysisRadical cyclizationPhotochemistryCombinatorial chemistryStereochemistryCatalysisOrganic chemistryMaterials sciencePolymerOptoelectronicsComposite materialSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsE-Government and Public Services