Phosphocreatine attenuates doxorubicin-induced cardiotoxicity by inhibiting oxidative stress and activating TAK1 to promote myocardial survival in vivo and in vitro
Chun Wang, Ling Hu, Shuang Guo, Qing Yao, Xiufen Liu, Bo Zhang, Xiangwen Meng, Xiaosong Yang
Topics & Concepts
CardiotoxicityNecroptosisOxidative stressPharmacologyDoxorubicinApoptosisMedicineProgrammed cell deathIn vivoChemistryInternal medicineBiochemistryToxicityBiologyChemotherapyBiotechnologyChemotherapy-induced cardiotoxicity and mitigationChemotherapy-induced organ toxicity mitigationCardiac Ischemia and Reperfusion