Rhodium-catalyzed atroposelective access to trisubstituted olefins <i>via</i> C–H bond olefination of diverse arenes
Xiaohan Zhu, Ruijie Mi, Jie Yin, Fen Wang, Xingwei Li
Abstract
C–H olefination of alkynes has been realized as an efficient approach to access axially chiral trisubstituted olefins, where two classes of arenes have been identified.
Topics & Concepts
RhodiumCatalysisChemistryOrganic chemistryCombinatorial chemistryMedicinal chemistryAxial and Atropisomeric Chirality SynthesisCatalytic C–H Functionalization MethodsMolecular spectroscopy and chirality