Litcius/Paper detail

Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy

Marie Siwicki, Nicolas A. Gort-Freitas, Marius Messemaker, Ruben Bill, Jeremy Gungabeesoon, Camilla Engblom, Rapolas Žilionis, Christopher Garris, Genevieve M. Gerhard, Anna Kohl, Yunkang Lin, Angela E. Zou, Chiara Cianciaruso, Evangelia Bolli, Christina Pfirschke, Yi-Jang Lin, Cécile Piot, John E. Mindur, Nilesh P. Talele, Rainer H. Köhler, Yoshiko Iwamoto, Mari Mino–Kenudson, Sara I. Pai, Claudio DeVito, Thibaud Koessler, Doron Merkler, Alexander Coukos, Alexandre Wicky, Montserrat Fraga, Christine Sempoux, Rakesh K. Jain, Pierre‐Yves Dietrich, Olivier Michielin, Ralph Weissleder, Allon M. Klein, Mikaël J. Pittet

2021Science Immunology80 citationsDOIOpen Access PDF

Abstract

1-promoting immunotherapy, suggesting distinct mechanisms of toxicity and antitumor immunity.

Topics & Concepts

ImmunotherapyToxicityCancer immunotherapyNeutrophileKupffer cellImmunologyCancerMedicineLiver cancerCancer researchBiologyInflammationImmune systemInternal medicineImmune cells in cancerCancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses