Comparative-Effectiveness of Oral Beta-Lactams and Fluoroquinolones for Stepdown Therapy in Patients with Enterobacterales Bloodstream Infections: A Retrospective Cohort Study
Lauren Bjork, Teri Hopkins, Linda Yang, Chengwen Teng, Xavier Jones, José Cadena, Elizabeth Walter, Christopher R. Frei
Abstract
This study suggests that BLs may be as effective as FQs for oral stepdown treatment of Enterobacterales BSI without the potential associated risks. Furthermore, in the setting of FQ-resistant Enterobacterales BSI secondary to urinary source, third generation oral cephalosporins (i.e., cefpodoxime) may be reasonable alternatives.
Topics & Concepts
MedicineInterquartile rangeInternal medicineRetrospective cohort studyBacteremiaIntensive care unitLogistic regressionCohortSurgeryAntibioticsMicrobiologyBiologyAntibiotics Pharmacokinetics and EfficacyAntibiotic Use and ResistanceAntibiotic Resistance in Bacteria