Immunization of mice with vaccinia virus Tiantan strain yields antibodies cross-reactive with protective antigens of monkeypox virus
Lei Yang, Yingshan Chen, Sha Li, Yuan Zhou, Yongli Zhang, Rongjuan Pei, Xinwen Chen, Yun Wang
Abstract
• The first study describing the cross-reactivity of antibodies elicited by a Chinese smallpox vaccine against MPXV. • Mice immunized with vaccinia virus Tiantan strain yield antibodies cross-reactive with MPXV protective antigens. • Cross-reactivities of VTT-elicited antibodies against monkeypox protective antigens are ranging from 33% to 94%.
Topics & Concepts
MonkeypoxVirologyVacciniaAntibodyAntigenVirusCross-reactivitySmallpox vaccineImmunizationMedical microbiologySmallpoxBiologyVaccinationImmunologyCross reactionsRecombinant DNAGeneBiochemistryPoxvirus research and outbreaksHerpesvirus Infections and TreatmentsBacillus and Francisella bacterial research