Origins and clonal convergence of gastrointestinal IgE <sup>+</sup> B cells in human peanut allergy
Ramona A. Hoh, Shilpa A. Joshi, Ji-Yeun Lee, Brock A. Martin, Sushama Varma, Shirley Kwok, Sandra C. A. Nielsen, Parastu Nejad, Emily Haraguchi, Priya S. Dixit, Swetha V. Shutthanandan, Krishna M. Roskin, Wenming Zhang, Dana Tupa, Bryan Bunning, Monali Manohar, Robert Tibshirani, Nielsen Fernandez‐Becker, Neeraja Kambham, Robert B. West, Robert G. Hamilton, Mindy Tsai, Stephen J. Galli, Rebecca S. Chinthrajah, Kari C. Nadeau, Scott D. Boyd
Abstract
Peanut-allergic patient GI tissues implicate local IgE class-switching and common IgH genetic rearrangements in pathogenesis.
Topics & Concepts
Immunoglobulin EImmunologyCD23BiologyIsotypeAllergyAntibodyFood allergyAllergenDuodenumGastrointestinal tractStomachMedicineMonoclonal antibodyInternal medicineBiochemistryFood Allergy and Anaphylaxis ResearchMonoclonal and Polyclonal Antibodies ResearchEosinophilic Esophagitis