Single-cell profiling of infiltrating B cells and tertiary lymphoid structures in the TME of gastric adenocarcinomas
Lizhou Jia, Tengqi Wang, Youcai Zhao, Shuyu Zhang, Teer Ba, Xingwang Kuai, Bin Wang, Ning Zhang, Wei Zhao, Zhiping Yang, Haishi Qiao
Abstract
< .05) results indicated more types of immune cells can be enriched in tissues with mTLSs than normal TLSs, and the density of mTLSs were higher than normal TLSs. Our findings provide novel insights for the signature of immune cells and tumor cells in the TME of gADC with TLSs and highlight the potential importance of IgA-mediated humoral immunity in gADC patients with TLSs.
Topics & Concepts
Immune systemBiologyImmunofluorescenceTumor microenvironmentLymphatic systemAntibodyImmunologyPathologyCancer researchMedicineImmune Cell Function and InteractionCancer Immunotherapy and BiomarkersIL-33, ST2, and ILC Pathways