Chelation-Controlled Stereospecific Cross-Coupling Reaction between Alkenes for Atroposelective Synthesis of Axially Chiral Conjugated Dienes
Dong‐Ting Dai, Meng‐Wei Yang, Zhiyuan Chen, Zi‐Lu Wang, Yun‐He Xu
Abstract
In this protocol, an efficient palladium-catalyzed asymmetric synthesis of axially chiral conjugated dienes via alkenyl C-H olefination is reported. The corresponding atropisomeric styrenes containing a conjugated diene scaffold were obtained in good yields with good enantioselectivities. This synthetic strategy features an easy operation, mild reaction conditions, a wide functionality tolerance, and high efficiency.
Topics & Concepts
ChemistryConjugated systemStereospecificityCoupling reactionDieneCombinatorial chemistryPalladiumConjugated dieneAxial symmetryCatalysisOrganic chemistryMonomerPolymerEngineeringStructural engineeringNatural rubberAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralitySphingolipid Metabolism and Signaling