MYO10 drives genomic instability and inflammation in cancer
Franklin Mayca Pozo, Xinran Geng, Ilaria Tamagno, Mark W. Jackson, Ernest G. Heimsath, John A. Hammer, Richard E. Cheney, Youwei Zhang
Abstract
significantly suppressed the growth of both human and mouse breast tumors in mice. Our data suggest that MYO10 promotes tumor progression through inducing genomic instability, which, in turn, creates an immunogenic environment for immune checkpoint blockades.
Topics & Concepts
Genome instabilityCancerInflammationBiomarkerImmunotherapyCancer immunotherapyComputational biologyBiomarker discoveryBiologyCancer biomarkersCancer researchBioinformaticsMedicineImmunologyGeneGeneticsDNA damageDNAProteomicsRNA modifications and cancerGalectins and Cancer Biologyinterferon and immune responses